绝经后血脂与骨密度关系的研究

The relationship between serum lipid and bone mineral density in post-menopausal women

目的探讨健康绝经后妇女血脂与骨密度（BMD）的关系。方法选择2002-2006年中国医科大学附属盛京医院体检的健康自然绝经妇女60例，使用美国NorlandXR-36双能X线骨密度仪测定第二腰椎（L2）、第三腰椎（L3）、第四腰椎（L4）、第二腰椎至第四腰椎（L2-L4）、股骨近端股骨颈（Neck）、粗隆（Troch）、Ward三角BMD。测定血清三酰甘油（TG）、血清总胆固醇（TC）、血清低密度脂蛋白胆固醇（LDL-C）、血清高密度脂蛋白胆固醇（HDL-C）。然后进行统计分析。结果HDL-C与腰椎（P〈0．01）及股骨近端（P〈0．05）BMD呈显著负相关，特别是腰椎和股骨近端Troch部位，在去除年龄和体重指数的影响后仍具有显著的相关性。结论绝经后妇女BMD与HDL-C呈负相关。

Objective To investigate the relationship between serum lipid and bone mineral density in post-menopausal women. Methods Bone mineral density （ BDM ） was measured at a variety of skeletal sites, including lumbar spine 2 （ L2 ） ,3 （ L3 ） ,4 （ L4 ） 2-4 （ L2-L4 ） , femoral neek （Neck）, trochanter （Troch）, Ward＇s triangle, using the Norland XR-36 dual-energy X-ray absorptiometer in northern Chinese healthy population-based sample of 60 post-menopausal women from 2002 to 2006 in our hospital. Serum lipid profiles of total cholesterol （ TC ） , low-density lipoprotein （LDL） , Triglyceride （TG） and high-density lipoprotein （HDL）were examined. Results HDL-C correlated inversely with BMD in both lumbar spine（ P 〈 0. 01 ）and proximal femur（ P 〈 0. 05 ）. And these relationships remained after the age and body mass index were adjusted. Conclusion BMD was related with serum HDL-C in northern Chinese post-menopausal women.