Livin在小细胞肺癌中的表达及与p53相关性研究

Expression of Livin in small cell lung cancer and its correlation with p53

目的探讨凋亡抑制蛋白Livin在小细胞肺癌（SCLC）组织中的表达及其与p53之间的关系。方法采用免疫组织化学染色S-P法检测Livin和p53在30例SCLC组织和16例癌旁正常肺组织中的表达情况。结果Livin在SCLC组织中的表达率为56．67％，明显高于癌旁正常肺组织的12．50％（P〈0．01）。Livin的表达与患者年龄、性别、肿瘤的TNM分期、淋巴结转移和肿瘤大小均无关（P〉0．05）。30例SCLC组织中有14例（46．67％）p53表达，而16例癌旁正常肺组织中无p53表达，两者之间差异有统计学意义（P〈0．01）。在SCLC组织中Livin与p53表达呈正相关（P〈0．01）。结论Livin在SCLC组织中异常表达，有望成为SCLC诊断和基因治疗的新靶点。Livin与p53的异常表达可能在SCLC癌变中起协调作用。

Objective To study the expression of Livin and its relationship with expression of p53 in small cell lung cancer （SCLC）. Methods Immunohistochemical S-P method was used to detect the expression of Livin and p53 protein in 30 SCLC tissues and 16 para-cancerous lung tissues. Results Livin protein was expressed in 17 of 30 SCLC tissues（56.67 % ）, but Livin protein showed low levels in para-cancerous lung tissues （ 12.50% ） ,P 〈 0.01. There was no significant correlation between positive Livin protein expression and age, sex, TNM staging , lymph node metastasis and tumor diameter （P〉 0.05）. p53 protein Was expressed in 14 of 30 SCLC tissues（46.67%）, but p53 protein was no expressed in para-cancerous lung tissues,P〈 0.01. The expression of Livin protein was positively related to the expression of p53 protein （P〈 0.01 ）. Conclusions The aberrant expression of Livin may be a new target for diagnosis and gene treatment of SCLC. The aberrant expression of Livin and p53 may play synergetic role in process of carcinogenesis of SCLC.