氟伐他汀对不稳定型心绞痛患者血清白介素-18和肿瘤坏死因子α干预的研究

Effects of Fluvastatin on Blood Levels of Interleukin-18 and TNFα in Patients with Unstable Angina Pectoris

目的研究氟伐他汀对不稳定型心绞痛患者血清白介素-18(IL-18)和肿瘤坏死因子α(TNF)α的影响。方法选择2006年9月至2007年7月79例不稳定型心绞痛患者,入院后随机分为2组:氟伐他汀干预组42例:常规药物治疗基础上加用氟伐他汀40 mg/d;对照组37例:常规药物治疗。分别于药物治疗前、药物治疗后2周采集静脉血,测定血清IL-18和TNFα的浓度。结果药物治疗后,对照组(P<0.05)及氟伐他汀干预组(P<0.01)血清IL-18和TNFα浓度均明显降低;氟伐他汀干预组血清IL-18(P<0.01)和TNFα(P<0.01)浓度明显低于同期对照组。结论氟伐他汀可明显降低不稳定型心绞痛患者血清IL-18和TNFα浓度。

To investigate the effect of fluvastatin on blood levels of interleukin-18 and TNFα in unstable angina pectoris. Methods 79 patients with unstable angina pectoris from September,2006 were randomized into two groups： control group;fluvastatin treating group（fluvastatin 40mg/d）. Serum patients with to July,2007 levels of IL- 18 and TNFαwere measured before and after two weeks treatment .Result After treatment, in fluvastatin treating group （P〈0.01） and the control group（P〈0.05）, the serum levels of IL-18 and TNFαdecreased distinctly ; After treatment,the serum levels of IL-18 （P〈0.01）and TNFα （P〈0.01）in fluvastatin treating group are distinctly lower than that in the control group .Conclusion The result suggests that fluvastatin can lead to a detectable decrease in serum levels of IL-18 and TNFαin patients with unstable angina pectoris.