急性脑梗死患者血浆C-反应蛋白水平研究

Study on the serum level of C-reactive protein in acute cerebral infarction

目的:探讨急性脑梗死患者血浆C-反应蛋白(CRP)水平与其病情严重程度之间的关系。方法:对40例脑梗死患者发病后24小时内的血CRP进行测定,并进行神经功能缺损评分。结果:脑梗死后24 h血CRP浓度即开始升高,CRP在脑栓死患者、动脉血栓性脑梗死患者之间差异无显著性,两者较腔隙性脑梗死患者血CRP增高(P<0.01)。病情越重血浆CRP水平越高。结论:血浆CRP是判断脑梗死病情轻重和预后的特异性指标,适时终止或减轻炎症反应损害,可以降低脑梗死的死亡率及并发多脏器衰竭的危险。

Objective：To inv.estigate the relationship between the serious extent of the disease after cerebral infarction （CI）and Creactive protein（CRP）. Methods：Tbe concentration of CRP in 40 patients with CI was measured within 24 hours.AU patients were scored by CNDF based on deficit in their clinical neurological function.Results： Our results showed that the level of CRP was markedly increased after CI in 24 hours. The serum levels of CRP were significantly higher in patients with embolic cerebral infarction and thrombotic brain infarction than in those with lacunar cerebral infarction. There was no statistical difference in the serum concentration of CRP in emboIic cerebral infarction and thrombotic brain infarction （P〉0.05）. It showed a highest serum CRP level in severe patients. Conclusion：CRP was an important prognosis marker for CI. If stopping or relieving the inflammatory reaction in time,we could moderately lower CRP and reduce the death rate of this disease.