代谢综合征与中青年脑梗死及颈动脉硬化的相关性研究

The important role of metabolic syndrome in acute cerebral infarction in the middle-aged and youth

目的 探讨代谢综合征与中青年急性脑梗死及颈动脉硬化的关系。方法对确诊急性脑梗死年龄在35～60岁之间患者198例，根据代谢异常分为代谢综合征组和非代谢综合征组，分别对其进行临床和颈部血管超声分析。结果代谢综合征组112例（56．5％），吸烟饮酒者比例高，脑梗死的复发率高于非代谢综合征组；代谢紊乱主要表现为肥胖、血压高、高空腹血糖、高甘油三酯血症及低高密度脂蛋白胆固醇血症；代谢综合征组纤维蛋白原升高明显，且颈动脉粥样硬化及斑块形成比例高。结论代谢综合征通过促使颈动脉粥样硬化及血栓形成，导致中青年急性脑血管意外的发生增加，在中青年急性脑梗死的发生中具有重要作用。

Objective To explore the role of metabolic syndrome in acute cerebral infarction in the mlddle-aged and youth. Methods Totally 198 patients with the age between 35 to 60 were selected. Acute cerebral infarction was confinned by brain CT or MRI. According to the revised ATPⅢ definition, all the patients were divided into two groups： metabelic syndrome group （MS） and non-metabollc syndrome group （nMS）. Results The prevalence of metabolic syndrome was high, more than half of the patients belonging to the MS. The rate of recurrence was much higher in patients with MS than nMS. Compared with the nMS group, the BMI, FBG and TG increased while HDL-C decreased significantly in pa- tients with MS group. Fihrinogen was also found elevated in MS group. Carotid and vertebral atherosclerosis especially plaque were detected much more in MS than those of nMS. Conclusion MS may play an important role in cerebral infarction in middle-aged and youth.