摘要
应用粒细胞集落刺激因子治疗心肌梗死后心室重塑是近年来心血管病学领域的研究热点之一。尽管其疗效在绝大多数动物实验及部分临床研究中得到了肯定,但目前粒细胞集落刺激因子究竟能否给心肌梗死患者带来益处尚无定论,而且其具体作用机制亦未被完全阐明。现介绍应用粒细胞集落刺激因子治疗心肌梗死后心室重塑的基础及临床研究现状,并对其有报导的几个主要作用机制给予简要综述。
Recently the granulocyte colony-stimulating factor （ G-CSF ） in the treatment of ventricular remodelling after myocardial infarction has been intensively studied. Although its efficacy has been supported by the majority of the animal studies and some clinical trials, it is still not possible to draw the conclusion that G-CSF can definitely bring benefits to patients with myocardial infarction. Moreover,the exact mechanisms underlying this phenomenon have not been fully understood. This review aims to show the progress in the research into G-CSF in the treatment of ventricular remodelling after myocardial infarction in both preclinical and clinical trials, and also summarizes recently documented mechanisms.
出处
《心血管病学进展》
CAS
2008年第3期441-444,共4页
Advances in Cardiovascular Diseases
关键词
粒细胞集落刺激因子
心肌梗死
心室重塑
granulocyte colony-stimulating factor
myocardial infarction
ventricular remodelling
