稀盐酸萃取林可霉素药品中B组分的传质研究

Mass transfer in lincomycin-B extraction by low concentration hydrochloric acid

采用双膜理论对酸水萃取正丁醇溶剂中林可霉素B组分的传质过程进行了分析,分析结果表明传质阻力主要集中在滴内。在往复振动筛板萃取塔内,对酸水萃取正丁醇溶剂中林可霉素B组分进行了实验研究,考察了输入能量和通量对总传质系数的影响。研究表明:虽然输入能量可以强化滴外传质,但对总传质系数的影响却较小;而通量的增加使不同液滴间的碰撞、聚合、再分散作用加强,从而强化了液滴内传质,因此通量对总传质系数的影响比较大。所以,对于酸水萃取正丁醇溶剂中林可霉素B组分这类传质阻力主要集中在滴内的物系,在设计往复振动筛板萃取塔时不应将提高输入能量作为强化传质的主要控制手段,而是提高通量。

The mass transfer in lincomycin-B extraction by low concentration hydrochloric acid was studied in the reciprocating sieve plate extraction column with n-butanol as solvent,and low concentration hydrochloric acid as extractant.The analysis by double film theory indicates that the mass transfer inside droplets is a controlling step.The experiment results show that the input energy can enhance the mass transfer outside the droplets,but it has less influence on overall mass transfer coefficient;the increase in flux can enhance the mass transfer inside droplets by the droplets impacting,getting together,re-dispersing; and the flux has more influence on overall mass transfer coefficient.Therefore for the system of mass transfer inside droplets,the main controlling parameter of enhancing the mass transfer is not input energy but flux when the reciprocating sieve plate extraction column is designed.