含磷脂胆碱新型水凝胶的制备及性能初探

The preparation of phosphorylcholine copolymer hydrogels and their characterization

用具有高亲水性和优良生物相容性的磷脂胆碱化合物改性HEMA／NVP，制备新型角膜接触镜水凝胶，并初步探讨其对水凝胶性能的影响。在光引发剂IRGACURE2959作用下，以HEMA和NVP为主要单体，加入一定量的2-甲基丙烯酰氧乙基-2’-三甲胺乙基磷酸酯·内盐（MPC），紫外光引发自由基聚合制备PHEMA／NVP-MPC水凝胶。得到的水凝胶在红外光谱（FTIR）中呈现了磷酰胆碱结构特征吸收峰。当MPC含量由0增加至59，6时，平衡含水率由48．329，6提高到53．669，6，透光率由36．559，6提高到989，6以上，抗张强度在0．76～0．35MPa之间。采用磷脂胆碱改性HEMA／NVP制得新型水凝胶，平衡含水率和透光率得到显著改善，可能成为角膜接触镜材料的新选择。

In this work 2-（methacryloyloxy） ethyl-2-（trimethylammonium） ethyl phosphate（MPC） was synthesized using 2-hydroxyethylmehtacrylate（HEMA）, and MPC was brought into the PHEMA/NVP gels in order to improve their performances. The PHEMA/NVP-MPC gels were prepared by using UV polymerization,identified by FTIR test. The equation water content was enhanced from 48.32% to 53.66 %, the transparency could be increased most to 98% by the origin 36.55% and the tensile strength was in the range of 0. 76-0. 35MPa when MPC content increased from 0-5% of these new gels. The results showed that the equation water content and the transparency of the PHEMA/NVP-MPC gels were better than the PHEMA/NVP gels,and it could be a new choice of the contact lens material .