非小细胞肺癌预后相关的多因素分析

Analysis of Multivariate Clinicopathological Character Related to Prognosis in Non-small Cell Lung Cancer

目的:分析非小细胞肺癌的临床病理特点与预后的相关因素。方法:应用SPSS软件回顾分析80例获得随访资料的非小细胞肺癌患者的预后相关因素。结果:(1)TNM分期、Ki-67标记指数以及微血管密度是预后的独立危险因素。(2)耐药基因GST-π和病理类型是预后的相对危险因素。(3)患者年龄、性别、病程长短、肿瘤大小、部位、有无坏死与预后无显著相关。结论:TNM分期是非小细胞肺癌最重要的预后独立指标,其次为Ki-67标记指数、微血管密度,而肿瘤耐药基因GST-π和病理类型则是预后相对指标。

Objective： To evaluate the relationship between clinicopathologic characteristics factors related to prognosis in non-SCLC. Methods：80 casas were analyzed and compared by univariate survival and multivariate analysis. Results： （1） TNM Staging,ratio of Ki-67 positivity and microvessel density were independent prognostic factor in non- SCLC. （2）The type of pathology and positive rates of GST-π were relative prognostic factor in non-SCLC. （3）Age,sex, size of tumor,course and cellular necrosis were not correlated with prognosis in non-SCLC. Conclusion ：The TNM Staging is the most critical factor. The next is ratio of Ki-67 positivity and the third is microvessel density, while the type of pathology and positive rates of GST-π are relative prognostic factor in non-small cell lung cancer.