连翘的化学成分

Chemical Constituents from Forsythia suspensa

AIM:To study the constituents of Forsythia suspensa(Thunb.) Vahl and find out the bioactive compounds.METHODS:The chemical constituents were isolated by various column chromatographic methods and the structures of the compounds were elucidated by spectral analysis.RESULTS:Nine compounds were obtained from acetic ester extracts of Forsythia suspensa(Thunb.)Vahl and their structures were identified as phillygenin(Ⅰ),epipinoresinol(Ⅱ),phillyrin(Ⅲ),(-)isolarlci-resinol(Ⅳ),betulinic acid(Ⅴ),2α-hydroxy betulinic acid(Ⅵ),oleanolic acid(Ⅶ),ursolic acid(Ⅷ) and 2α,23-hydroxy ursolic acid(Ⅸ)from the EtoAc extract.CONCLUSION:Compounds Ⅵ and Ⅸ are isolated from this plant and this genus for the first time.

AIM： To study the constituents of Forsythia suspensa （Thunb.） Vahl and find out the bioactive compounds. METHODS： The chemical constituents were isolated by various column chromatographic methods and the structures of the compounds were elucidated by spectral analysis. RESULTS： Nine compounds were obtained from acetic ester extracts of Forsythia suspensa （Thunb.）Vahl and their structures were identified as phillygenin （ Ⅰ ）, epipinoresinol（ Ⅱ ）, phillyfin （Ⅲ）, （-） isolarlciresinol（Ⅳ）, betulinic acid （Ⅴ）, 2α-hydroxy betulinic acid （Ⅵ）, oleanolic acid（Ⅶ）, ursolic acid （Ⅷ） and 2α, 23-hydroxy ursolic acid（Ⅸ） from the EtoAc extract. CONCLUSION： Compounds Ⅵ and Ⅸ are isolated from this plant and this genus for the first time.