氯吡格雷治疗急性非ST段抬高心肌梗死的临床观察

Clinical Observation of Therapy of Clopidogrel to Acute Non-ST Elevation Myocardial Infarction

目的:观察氯吡格雷治疗急性非ST段抬高心肌梗死(NSTEMI)的临床疗效及安全性。方法:急性非ST段抬高心肌梗死(NSTEMI)60例随机分为治疗组和对照组,对照组采用低分子肝素、阿司匹林及其他抗心绞痛药物,治疗组在以上治疗的基础上加用氯吡格雷首次顿服300mg,次日起75mg/d,连服2周。结果:治疗组能明显减少心绞痛发作频率(P<0.05),改善临床症状,对改善缺血性ST段压低明显优于对照组(P<0.05),且对出、凝血指标影响不大(P>0.05)。结论:在常规抗心绞痛治疗基础上加用氯吡格雷对NSTEMI安全有效。

Objective： To observe the clinical effect and safety in treatment of non-ST elevation myocardial infarction （NSTEMI） with clopidogrel. Methods： 60 patients with acute NSTEMI were divided into treatment and control group randomly. Control group was administered by Low Molecular Heparin, Aspirin and other anti-anginal drugs. Clopidogrel initial doses of 300 mg and followed 75 mg/d for two weeks were combined in treatment group. Results： Treatment group significantly reduction of rate of cardiac angina （P 〈 0.05）. Clinical symptoms and ischemic ST segment depression were improved than control group（P 〈 0.05）, and had a small influence on index of blood clotting （P 〉 0.05）.Conclusions： The addition of clopidogrel to basic anti- cardiac angina treatment would be more effective and safety to NSTEMI.