某部人群肾综合征出血热流行特征与基因分型研究

A study on genotyping and epidemiologic characterization of hemorrhagic fever with renal syndrome in an army group of population

目的了解某部人群肾综合征出血热(HFRS)流行特征及其感染型别,为本病防治工作提供科学依据。方法收集某部的疫情资料及相关信息资料,进行整理分析。同时采集HFRS疫区近期患者血清,应用RT-nested PCR结合SSCP对病人血清进行基因分型。结果某部1991-2006年报告病例403例,以散发为主,仅个别情况下长期密切接触疫源地才偶见局灶性暴发。报告病例呈现逐年下降趋势,2001年后呈零星散发;病例多集中在C、G、M等单位;以20～40岁发病居多;患者以战士为主,占72.21%;发病季节以春夏季高峰为主。基因分型结果证实当地近年来HFRS疫区从HTN向SEO转变,目前已经演变成以SEO为主的疫区。结论基本摸清某部近年HFRS流行特征,基因分型证实当地已经演变成以SEO为主的混合型疫区。

To understand the epidemiologic characterization and the types of infection of hemorrhagic fever with renal syndrome（HFRS） for the sake of providing the scientific basis for the control and prevention of this illness, certain epidemic data and the related information from the army group were collected and analyzed. Meanwhile,sera of patients with HFRS in the infection area were collected and the genotyping of HFRS virus from patients＇s sera was performed by using the RT-nested PCR together with single-strand conformational polymorphism（SSCP）. It was found that from 1991 to 2006, 403 cases of HFRS were reported in this army group most of these cases were found sporadically. Only few cases occurred after a long time contact with the natural loci of infection. The incidence of infection declined year by year, and only few individual cases were discovered in 2001. Cases were concentrated in C,G,M units,most of them were soldiers of 20 to 40 years old,accounting for 72.21%. The illness occurred most likely in spring and summer with two high-peaks in one year. Results in genotyping revealed that a transformation from HTN to SEO in the HFRS infection area could be detected in recent years and SEO has evolved to the main genotype in the infection area at present.