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血红素氧化酶-1在胃癌组织中的表达及意义 被引量：3

Expression of Heme Oxygenase-1 in Human Gastric Cancer
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摘要 目的研究人胃癌组织中血红素氧化酶-1(HO-1)的表达情况。方法采用免疫组化和RT-PCR等方法检测46例人胃癌组织(C组)、癌旁3 cm组织(M组)和第1、2站淋巴结(L1、L2组)中HO-1的表达水平,并与正常胃组织作对照(N组)。结果胃癌组织HO-1 mRNA表达水平最高,与M组、L1、L2组相比差异有统计学意义(P<0.01);M组、L1、L2组HO-1 mRNA表达显著强于N组(P<0.05),但组间相比差异无统计学意义(P>0.05)。结论胃癌组织中HO-1呈高表达状态,可能对肿瘤细胞的生长提供有利条件。 Objective To study the expressions of heme oxygenase-1 mRNA in human gastric cancer. Methods The expressions of heme oxygenase-1 mRNA in gastric cancer（C group） , 3 cm margin tissue（ M group） and lymph node （L1, L2 group） with immunohistochemical method and RT-PCR technique, the normal gastric tissues as control（N group）. Results The expressions of heme oxygenase-1 mRNA in gastric cancer were significantly higher than those in 3 cm margin tissues or in lymph node, P 〈0.01 ;and there was no significant difference in the expressions of heme oxygenase-1 mRNA among M group, L1 group and L2 group. Conclusions The expressions of heme oxygenase- 1 in human gastric cancer might provide advantage for its growth.
作者 张黎 程力 田飞 崔彬 张紧
机构地区 山东大学附属山东省立医院普外科 实验中心 病理科
出处 《肿瘤基础与临床》 2008年第3期211-213,共3页 journal of basic and clinical oncology
关键词 血红素氧化酶-1 胃肿瘤 淋巴结 heme oxygenase-1 gastric tumor lymph node
分类号 R735.2 [医药卫生—肿瘤]
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参考文献9

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同被引文献47

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肿瘤基础与临床
2008年 第3期

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