大剂量^(131)I治疗分化型甲状腺癌的临床观察

Clinical Observation of High Dose ^(131)I for Remnant Thyroid Tissue Ablation

目的分化型甲状腺癌的功能性转移灶具有吸收和浓聚131I的能力,利用131I的β射线有效破坏转移性癌灶,达到治疗目的。方法和外科合作,采用先行手术,术后恢复后口服大剂量131I,治疗后采用甲状腺激素替代疗法的综合治疗方案。按照病理类型、服碘次数、转移情况、毒副反应、显像情况等进行分类统计。结果131I治疗甲状腺癌与患者一般情况、病理、转移、术式及病灶吸碘情况有关。结论131I内照射治疗具有一定靶向性,利用131Iβ射线有效破坏转移癌灶,疗效肯定,但需根据患者的不同情况调整治疗方案。

Objective To evaluate the effect of ^131I in the postoperative treatment of well-differentiated thyoid carcinoma. Methods High dose ^131 I treatment in the postoperative patients, statistical analysis by pathology,times, adverse reaction, metastasis and results of SPECT. Results The effect of ^131 I therapy was concerned with patients＇ general state, pathology, metastasis, operation modus and the resorption of tissues. Conclusions The treatment of ^131 I is safe and effective with little adverse reactions, and it need be adjusted by different patients.