轻度认知功能障碍患者血脂代谢的变化

Change of metabolism of serum lipids in patients with mild cognitive impairment

目的研究轻度认知功能障碍(MCI)患者血脂代谢的变化。方法测定并比较60例MCI患者和100例年龄相当的正常对照者(对照组)血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)水平。结果MCI患者TC、TG和LDL水平明显高于对照组,HDL水平明显低于对照组,差异有统计学意义(P<0.05)。结论MCI患者存在明显的脂质代谢紊乱,TC、TG和LDL水平的升高或HDL的降低可能对发病有一定的影响。

Objective To study the change of metabolism of serum lipids in patients with mild cognitive impairment （MCI）. Methods The serum levels of total cholesterol （ TC ） , triglyceride （TG） , low density lipoprotein （LDL） and high density lipoprotein （HDL） were measured in 60 patients with MCI and 100 age-matched normal controls. Results The serum levels of TC, TG and LDL were significantly higher and HDL significantly lower in patients with MCI than in normal controls（ P 〈 0.05）. Conclusion Metabolic disturbance of serum lipids exists in patients with MCI. The increase of TC, TG and LDL and decrease of HDL may have effects on the onset of MCI.