动态动脉硬度指数与脉搏波速度的相关性研究

Study on correlation of ambulatory arterial stiffness index and pulse wave velocity

目的研究动态动脉硬度指数（AASI）与脉搏波速度（PwV）的相关性，探讨AASI对动脉硬化程度的评价价值，并分析AASI的影响因素。方法入选患者100例，进行臂-踝PwV测量，并同时进行24h动态血压监测（ABPM），计算AASI。应用直线相关分析判定AASI与PwV的相关性。并应用多因素逐步回归分析判定AASI的影响因素。结果AASI与PWV和年龄显著正相关（PWV：r=0．516，P〈0．01；年龄：r=0．417，P〈0．01）。AASI与身高呈负相关（r=-0．223，P〈0．05）。多因素逐步分析结果表明，PWV是与AASI关系最密切的参数。结论AASI与PwV相关性良好，是一个反映动脉硬化程度的新指数。

Objective To study the correlation of ambulatory arterial stiffness index （AASI） and pulse wave velocity （PWV） , explore the evaluation of AASI on arterial stiffness and analyze the influential factors of AASI. Method One hundred patients were selected, brachial-ankle pulse wave velocity （baPWV） of all patients was measured, simultaneously 24-hour ambulatory blood pressure was examined, calculated AASI.AASI and baPWV were analyzed with correlation and regression analysis. Results AASI was positively and significantly correlated with PWV （r = 0.516, P〈 0.01 ） and age （r = 0.417, P〈 0.01 ）. AASI was negatively correlated with body height （r = -0.223, P 〈 0.05 ）. The multiple factor stepwise regression analysis showed that the regression of AASI with PWV were great significant. Conclusions AASI is positively and significantly correlated with PWV. It is a novel measure of arterial stiffness.