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特发性血小板减少性紫癜免疫紊乱状态的研究进展

Progress in immunologic deragement of idiopathic thrombocytopenic purpura
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摘要 特发性血小板减少性紫癜（ITP）是一种自身免疫性疾病，其病因和发病机制尚未完全明确。目前研究认为与免疫紊乱密切相关：急性期呈辅助T细胞（Th）1优势分化、缓解期呈Th2优势分化；CD4^＋T细胞是机体的重要调节细胞，在转录因子T-bet／GATA3的作用下，其激活后选择性地优势分化为Th1／Th2，通过分泌特征性细胞因子而发挥免疫作用；也有研究认为，ITP患儿自身反应性T细胞凋亡受到抑制，引起自身反应性T细胞克隆积聚，不断刺激B细胞产生自身抗体并激活细胞毒性T细胞，导致血小板持续破坏。
作者 张春霞(综述) 任少敏(审校)
机构地区 内蒙古医学院附属医院儿科
出处 《国际儿科学杂志》 2008年第3期246-247,共2页 International Journal of Pediatrics
基金 内蒙古自然科学基金资助项目（200711020946）
关键词 紫癜 血小板减少性 特发性 转化因子 T淋巴细胞 细胞因子类
分类号 R554.6 [医药卫生—血液循环系统疾病] R644 [医药卫生—外科学]
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参考文献14

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二级参考文献21

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国际儿科学杂志
2008年 第3期

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