微量白蛋白尿与冠心病的关系

The relationship between microalbuminuria and coronary artery disease

目的探讨微量白蛋白尿(MA)与冠心病的关系及其对冠心病的预测价值。方法入选320例拟诊冠心病并行冠脉造影的患者,对所有患者进行病史采集、常规化验检查,并在入院48小时内测其尿白蛋白滤过率(UAER)。结果MA阳性组冠心病发病率(68.1%)明显高于MA阴性组(45.1%)(P<0.01),且MA阳性组病情重、冠脉多支病变的可能性更大。MA是独立于性别、年龄、吸烟、高血压病史、糖尿病史、血脂异常的冠心病独立危险因素(OR=2.11,P<0.01,95%Cl:1.18￣3.74)。结论MA是冠心病的独立危险因素,检测UAER有助于识别冠心病高危人群。

Objective To examine the relationship between microalbuminuria（MA） and coronary artery disease（CAD）, investigate the value of MA in predicting the risk of CAD. Methods We studied 320 patients who were assumed CAD. All patients underwent coronary artery angiography, UAER and hemostatic factors evaluation in addition to history collection. Results CAD mobidity in patients with positive MA is significantly higher than in those with negative MA （68.1%; 45.1%, P〈0.01）. The number of vessels deseased is more in patients with positive MA. MA is the risk factor of CAD independent of sex, age, smoking, hypertention, diabetesmellitus, dysllpidemia（OR=2.11, P〈0.01, 95% CI：1.18-3.74）. Conclusion MA is the independent risk factor of CAD. The detection of UAER is useful in identifying high risk patients of CAD.