淋球菌的临床检验及药物敏感试验

Clinincal test and drug sensitivity test of gonococci

目的通过数据分析了解涂片及培养2种检测淋球菌方法的差异性,提高阳性率。方法按《全国临床检验操作规程》进行操作。并对确诊病例作药敏试验。结果286例标本中用涂片法有200例阳性,阳性率为69.9%(200/286),用培养法,有166例阳性,阳性率为72.4%(207/286)。如将标本只做培养,漏检率为14.3%(41/286),只做涂片漏检率为2.4%(7/286)。琳球菌敏感性最高的是阿奇霉素。结论淋球菌最好用两种方法同时检测,可使阳性率有所提高。如2种方法任选其一,应根据不同类型的淋球菌感染选择恰当的检测方法。在湘潭地区,阿奇霉素、头孢曲松和壮观霉素仍可作为淋病治疗的首选药物。

Objective Understanding the difference of two methods, smear and culture, in detecting gonococcus and improving the positive rate. Methods Operating according to ＂rules of the clinical examination＂ and doing drug sensitivity test. Results In smear group, 200 out to 286 samples are positive, with the positive rate 69.9% （200/286）,while in culture group, 166 out of 286 samples are positive, with the positive rate 58.1% （41/286）. If samples are only smeared, the losing ratio is 2.4% （7/286）. Gonococcus is most sensitive to Azithromycin. Conclusions The preferred choice to detect gonococcus in using the two methods at the same time, which will improve the positive rate. According to the different types of Neisseria gonorrhocae infection made appropriate choice of methods to increase the accuracy of diagnosis. In Xiangtan area, Azithromycin, ceftriaxone and spectinomycin can still be used as primary agents to cure gonorrhea.