湖南湘西地区195例淋巴瘤病理类型分析

Analysis on pathological subtypes of 200 cases of malignant lymphoma in Hunan western Hunan area

目的根据WHO(2001年)淋巴瘤的新分类标准,对湖南湘西地区淋巴瘤的病理类型及分布特征进行探讨。方法收集我院已病理诊断的200例恶性淋巴瘤(ML),复习其组织学、免疫组化标记和临床特点,按WHO新分类标准进行了重新评估。结果200例中有5例为误诊,确诊195例中霍奇金淋巴瘤(ML)12例(6.2%),非霍奇金淋巴瘤(NHL)183例(93.8%),183例NHL中发生于淋巴结者40.4%,结外占59.6%。分型B细胞肿瘤63.9%,T和NK细胞肿瘤32.8%;前5位最常见类型为弥漫性大B细胞淋巴瘤(DLBL)、鼻型结外NK/T细胞淋巴瘤(NK/T-L)、MALT型结外边缘区B细胞淋巴瘤、非特殊型外周T细胞、滤泡性淋巴瘤,共占NHL的74.3%。结论我国湖南湘西地区,结外淋巴瘤的比率超过结内,NHL以DLBL和NK/T-L为最多见。NK/T-L和外周T细胞淋巴瘤的发病率较西方国家高,但滤泡性淋巴瘤和B小细胞淋巴瘤的发病率较西方国家低。

Objective According to the latest Wold Health Organizatong（WHO2001）classification, carried on the discussion to Hunan western Hunan area lymphoma＇s pathology type and the distribution characteristic. Methods Collects my courtyard already pathological diagnosis 200 example malignant lymphoma （ML）, reviews its histopathologie, immunophenotypie and the clinical characteristic, the new classified standard carried on according to WHO has appraised. Results There were 5 eases error diagnostic in 200 eases, There were 12 eases （6.2%） of Hodgkin＇s lymphoma（HL） and 183 eases（93.8%） of non-Hodgkin＇s lymphoma（NHL）. In the 183 NHL cases, occurs in the lymph aode 40.4%, extranodal malignant lymphoma 59.6%. B-cell neoplasms accounted for 63.9% andT/NK-cell neoplasms for 32.8%. On subtyping, diffuse large B-cell lymphoma extranodal NK/T cell lymphona of masal type, extranodal marginal zone B-cell lymphoma of MALT type, unspecified peripheral T- cell lymphoma, and follicular lymphoma were the most common 5 subtypes and amounted to 74.3% of NHL Conclusion In our country Hunan western Hunan area, NHL as most sees take diffuse hrge B-cell lymphoma and Extranodal NK/T-cell lymphoma of nasal type. Extranodal NK/T cell lymphoma of nasal type and other peripheral T-cell lymphoma had a higher frequency, but B-small lymphocytic lymphoma and follicular lymphoma were less common in this group than in Western countries.