摘要
研究了纳米羟基磷灰石/聚碳酸酯(n-HA/PC)生物复合材料在模拟体液(SBF)中的表面变化,并用傅里叶红外光谱(FTIR)、X射线衍射仪(XRD)和扫描电子显微镜(SEM)对材料的表面变化进行了分析。结果表明,n-HA/PC生物复合材料在模拟体液(SBF)中浸泡后,表面会沉积碳酸化羟基磷灰石(CHA),随着浸泡时间的延长,沉积层变厚,CHA晶体形貌变得规整。对n-HA/PC复合材料进行了细胞实验,通过四唑盐(MTT)检测和扫描电镜观察,表明n-HA/PC复合材料无细胞毒性,细胞形态正常,是一种有应用前景的可承力骨修复替代材料。
The in vitro bioactivity of nano-hydroxyapatite/polycarbonate（n-HA/PC） composite was studied in SBF （simulated body fluid）. The sample surface was characterized by FTIR, XRD and SEM. The results show that n- HA/PC composite is chemically active in SBF, and the Ca and P ions of carbonated-apatite （CHA） deposit on the surface during soaking in SBF. The Ca-P precipitate on the surface of n-HA/PC composite was CHA. The layer of deposited CHA increases with time, and the morphology of CHA crystal gradually forms. By MTT and SEM analyses, the results show that n- HA/PC composite is not cell toxic and has a good biocompatibility to MG- 63 cells. Therefore, this kind of composite could be one of the best potential bioactive materials for the load bearing bone substitute.
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2008年第3期68-72,共5页
Acta Materiae Compositae Sinica
基金
国家“973”计划(2007CB936102)
