小剂量雷公藤佐治儿童糖皮质激素依赖性哮喘的效果

LOW-DOSE TRIPTOLIDE FOR CHILDREN WITH HORMONE-DEPENDENT ASTHMA

目的探讨小剂量雷公藤佐治糖皮质激素依赖性哮喘的效果。方法40例糖皮质激素依赖性哮喘病儿随机分为治疗组和对照组（n=20），两组病儿均给予吸人普米克干粉剂，在发作期吸人β2受体激动剂，严重时口服糖皮质激素治疗。治疗组在此基础上加用雷公藤0．5mg／（kg·d），分为2～3次口服，治疗6个月后评定疗效。结果治疗组在糖皮质激素较快减量的过程中峰值流速（PEFR）始终在预计值的80％以上，糖皮质激素的维持量明显小于对照组（t=-4．73，P〈0．01）。治疗后两组肺功能均较治疗前明显改善，治疗组肺功能优于对照组（t=2．493～3．476，P〈0．05）。结论小剂量雷公藤佐治糖皮质激素依赖性哮喘病儿效果满意。

Objective To assess the clinical effects of low-dose triptolide in the treatment of children with hormone-dependent asthma. Methods Forty children with this type of asthma were evenly divided into treatment group and control group. Inhalation of corticosteroid, and of β2 adrenergic receptor stimulant at onset, and oral corticosteroid for serious cases were given to both groups. For those in treatment group, low-dose triptolide （0.5 mg· kg^-1 · d^-1 , divided into 2-3 doses） were added. The efficacy was evaluated six months later. Results The peak expiratory flow rate exceeded 80 % of the predicted value in treatment group and the maintainance dose of corticosteroid was significantly lower than that in the controls （t=- 4.73, P〈0.01）. The pulmonary function of both groups improved after treatment, more improvement being seen in the treatment group （t=2. 493-3. 476, P〈0.05）. Conclusion Low dose of triptolid is effective as an adjuvant for children with hormone-dependent asthma.