老年局部晚期非小细胞肺癌放化综合治疗的疗效分析

Research of Radio-chemotherapy in Elderly Patients with Locally Advanced Non-small Cell Lung Cancer

目的分析70岁以上老年局部晚期非小细胞肺癌的放化综合治疗疗效,探讨综合治疗的可行性。方法对61例70岁以上老年局部晚期非小细胞肺癌的治疗结果进行分析,并以同期治疗的75例<70岁的局部晚期非小细胞肺癌作为对照。结果≥70岁组中位生存时间为18个月,1、3、5年生存率分别为78.15%、18.47%、10.39%;<70岁组中位生存时间为19个月,1、3、5年生存率分别为69.44%、18.27%、8.08%,两组的生存率差异无统计学意义。除≥70岁组骨髓抑制明显外,其他副反应两组无明显差异。结论老年局部晚期非小细胞肺癌的治疗尚无统一方案,适当的给予综合治疗是可行的。

Objective To analye the treatment of locally advanced non-small cell lung cancer in the 70 years old and over to research the possibility of combined therapy. Methods Sixty-one cases with locally advanced non-small cell lung cancer were over 70 years old and 75 cases with locally advanced non-small cell lung cancer were younger than 70 years old whose results were analyzed. Results Of the over seventy years old patients, the median survival time was 18 months, and the 1,3,5 year overall survival rates was 78. 15%, 18.47%and 10. 39% ;The median survival and the 1,3.5 year overall survival rates of the〈70 years old patients were 19 months and 69. 44%, 18. 27% ,8. 08%. The survival rates were similar in two groups. Toxicity was similar except leucopenia in two groups. Conclusion There is no standard method for elderly patients with locally advanced non-small cell lung cancer. It is feasible to take the treatment of radiotherapy combined chemotherapy.