期刊文献+

心型脂肪酸结合蛋白及其他心肌标志物检测在病毒性心肌炎中的临床意义 被引量:13

Heart type fatty acid-binding protein and other myocardial markers in viral myocarditis
下载PDF
导出
摘要 目的研究心型脂肪酸结合蛋白(H-FABP)检测在病毒性心肌炎(VMC)中的临床应用价值,并与常规检测项目肌酸激酶同功酶(CK-MB)、肌钙蛋白I(cTnI)进行比较,为VMC的诊断提供更好的指标。方法对临床确诊的40例VMC患儿,在不同的时间段进行上述三项指标的检测,并与40例健康人的检测结果进行比较。结果40例患儿的CK-MB在VMC起病后8~12h开始升高,24~48h达到高峰;cTnI在VMC起病后4~6h开始升高,12~24h达到高峰;H-FABP在VMC起病后2~4h即升高,8~12h达到峰值。三项指标高峰值与对照组比较差异均有统计学意义。结论CK-MB作为早期诊断指标欠佳,cTnI优于CK-MB,但不及H-FABP,H-FABP可作为VMC早期诊断的最佳指标。
出处 《临床儿科杂志》 CAS CSCD 北大核心 2008年第5期387-388,398,共3页 Journal of Clinical Pediatrics
关键词 心肌炎 心型脂肪酸结合蛋白 肌钙蛋白I myocarditis heart type fatty acid-binding protein troponin I
  • 相关文献

参考文献11

  • 1杨振华.应考虑在缺血性心脏病使用一些新的生化标记物[J].中华心血管病杂志,1997,25(5):327-327.
  • 2Adams JE 3rd, Sicard GA, Allen BT, et al. Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I [J]. N Engl J Med,2004,330(10): 670-674.
  • 3Bodor GS, Porter S, Landt Y, et al. The development of monoclonal antibodies and an assay for cardiac troponin Ⅰ with preliminary results in suspected myocardial infarction [J]. Clin Chem ,2004,38( 11 ) :2203-2214.
  • 4Smith SC,Ladenson JH,Mason JW,et al. elevetion of cardiac troponin Ⅰ associated with myocarditis experimental and clinical correlates [J ]. Circulation ,2005,95 ( 1 ) : 163- 168.
  • 5Ohkaru Y, Asayama K, Ishii H, et al. Development of a sandwich enzyme-linked immunosorbent assay for the determination of human heart type fatty acid-binding protein in plasma and urine by using two different monoclonal antibodies specific for human heart fatty acid-binding protein [J]. J Immunol Methods, 1995,178( 1 ) :99-111.
  • 6Keagten JA, Van Nieuweuhoven FA, Van Dieijen-Visser MP,et al. Distribution of myoglobin and fatty acid-binding protein in human cardiac autopsises [J]. Clin Chem, 2004,42(2) :337.
  • 7Van Nieuwenhoven FA ,Van der Vusse GJ ,Glatz JF. Membrane-associated and cytoplasmic fatty acid-binding proteins [J ]. Lipids, 1996,31 (Suppl) : 223-227.
  • 8Kleine AH ,Glatz JF,Van Nieuwenhoven FA,et al. Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man [J]. Mol Cell Biochem,2005, 116(1-2) : 155-162.
  • 9Knowlton AA, Burrier RE, Brecher P. Rabbit heart fatty acid-binding protein. Isolation,characterization and application of a monoclonal antibody [J]. Circul Res,2002,65 (4) :981-988.
  • 10Tanaka T, Hirota Y, Sohmiya K, et al. Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction [J]. Clin Biochem, 1991,24(2) : 195-201.

共引文献50

同被引文献200

引证文献13

二级引证文献83

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部