68例烧伤患者血清PA和CRP的检测及其临床意义

Determination of serum prealbumin and C-reactive protein in 68 burn patients and its clinical significance

目的探索烧伤患者血清前白蛋白(PA)与C-反应蛋白(CRP)的变化及其临床意义。方法68例烧伤患者按烧伤总面积大小分为小于15%组38例和大于50%组30例,健康对照组30例。伤后第一天,采用透射免疫比浊法分别测定3组人群血清CRP及PA的浓度。结果烧伤面积大于50%组CRP水平明显高于面积小于15%组,而PA水平烧伤面积大于50%组明显低于面积小于15%组,与CRP水平呈负相关。结论PA水平随着烧伤面积的增加而降低,PA作为烧伤后的炎症程度指标,有十分重要的意义。

Objective To investigate the change of serum prealbumin （PA） and C-reactive protein （CRP） in burn patients and its clinical significance. Methods Sixty eight cases of burn patients were divided into two groups, group Ⅰ [n=38, with total burn surface area less than 15% of total body surface area （TBSA）] and groupⅡ （n=30, with total burn surface area more than 50% of TBSA）. Thirty healthy people were set as healthy control group. Particle enhanced immunoturbidimetic assay was applied to detecting the serum levels of PA and CRP for all subjects on the day 1 after burns. Results The CRP level was much higher and serum level of PA was much lower in group Ⅱ than that of group Ⅰ , respectively. There existed significant negative correlation between PA and CRP level. Conclusion The level of serum PA decreases significantly along with total burn surface area expansion. PA can be used as a sensitive marker for estimation of inflammation degree after burns.