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血氧载体的研究现状及进展 被引量：2

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摘要 基于血红蛋白(Hb)和全氟化碳(PFC)乳剂的氧载体是目前研究较多的血液红细胞代用品,第一代Hb氧载体多为Hb与戊二醛等交联后的产物,具有较大的毒副作用;第二代Hb氧载体缩小了交联等处理后的产物相对分子质量,毒性小,易于生产。PFC乳剂则是另一种化学形式的血氧载体,部分产品已经商业化,并在临床使用。
作者 王昕 赵树铭
机构地区 第三军医大学西南医院输血科
出处 《国际检验医学杂志》 CAS 2008年第5期418-420,共3页 International Journal of Laboratory Medicine
基金 重庆市自然科学基金(CSTC。2004BB5074) 第三军医大学科研创新基金资助项目(NO2007XG51)
关键词 血液代用品 血红蛋白类 红细胞 氟碳化合物
分类号 R944 [医药卫生—药剂学]
  • 相关文献

参考文献13

  • 1范华骅,杨懿铭,钱开诚.血红蛋白衍生物类红细胞代用品研究进展[J].国际生物制品学杂志,2006,29(4):175-177. 被引量：4
  • 2Levy JH, Goodnough LT, Greilich PE, et al. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, doubleblind trial[J]. J Thorac Cardiovasc Surg, 2002, 124(1): 35-42.
  • 3Carson JL, Noveck H, Berlin JA, et al. Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion[J].Transfusion, 2002, 42(7):812-818.
  • 4Kerner T, Ahlers O, Veit S, et al. DCL-Hb for trauma patients with severe hemorrhagic shock: the European "On-Scene" multicenter study[J]. Intensive Care Med, 2003, 29(3): 378-385.
  • 5Tsai AG, Vandegriff KD, Intaglietta M, et al. Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics[J]. Am J Physiol Heart Cire Physiol, 2003, 285(4): H1 411- H1 419.
  • 6Winslow RM. Current status of blood substitute research: towards a new paradigm[J].J Intern Med, 2003, 253(5): 508- 517.
  • 7McCarthy MR, Vandegriff KD, Winslow RM. The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers[J].Biophys Chem, 2001, 92(1-2): 103-117.
  • 8Vandegriff KD, Malavalli A, Wooldridge J, et al. MP4, a new nonvasoaetive PEG-Hb conjugate [J]. Transfusion, 2003,43 (4) : 509-516.
  • 9Winslow RM, Lohman J, Malavalli A, et al. Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat[J].J Appl Physiol, 2004, 97(4): 1 527-1 534.
  • 10Young MA, Riddez L, Kjellstrom BT, et al. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine[J].Crit Care Med, 2005, 33(8): 1 794-1 804.

二级参考文献19

  • 1LU Xiuling, ZHENG Chunyang, XU Yuhong & SU Zhiguo National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China,School of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.Disuccinimidyl suberate cross-linked hemoglobin as a novel red blood cell substitute[J].Science China(Life Sciences),2005,48(1):49-60. 被引量：1
  • 2路秀玲,郑春杨,徐宇红,苏志国.辛二酸二琥珀酰亚胺酯交联血红蛋白制备红细胞代用品[J].中国科学（C辑）,2004,34(4):350-359. 被引量：4
  • 3Winsow RM.Current status of blood substitute research:towards a new paradigm.J Intern Med,2003,253:508-517.
  • 4Alayash AI.Oxygen therapeatics:can we tame haemoglobin? Nat Rev Drug Discov,2004,3:152-159.
  • 5Winslow RW.Targeted O2 delivery be low-P50 hemoglobin:a new basis for hemoglobin-based oxygen carriers.Artif Cells Blood Substit Immobil Biotechnol,2005,33:1-12.
  • 6Sakai H,Tsai AG,Kerger H,et al.Subcutaneous microvascular responses to hemodilution with red cell substitutes consisting of polyethyleneglycol-modified vesicles encapsulating hemoglobin.J Biomed Mater Res,1998,40:66-78.
  • 7Huang Y,Komatsu T,Nakagawa A,et al.Compatibility in vitro of albumin-heme (O2 carrier) with blood cell components.J Biomed Mater Res,2003,66:292-297.
  • 8Lu XL,Zheng CY,Shi XD,et al.Conjugate of bovine hemoglobin and human serum albumin as a candidate for blood substitute:characteristics and effects on rats.Artif Cells Blood Substit Immobil Biotechnol,2005,33:83-99.
  • 9Alayash AI.Oxidative mechanisms of hemoglobin-based blood substitutes.Artif Cells Blood Substit Immobil Biotechnol,2001,29:415-425.
  • 10Powanda DD,Chang TM.Cross-linked supplies oxygen without causing blood-brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion.Artif Cells Blood Substit Immobil Biotechnol,2002,30:23-37.

共引文献13

同被引文献122

引证文献2

二级引证文献20

国际检验医学杂志
2008年 第5期

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