乌司他丁对全身炎性反应综合征主要炎性介质的调节作用

Ulinastatin＇s Modulation on the Main Inflammatory Mediators of the Systemic Inflammatory Response Syndrome

许多感染和非感染因素可以导致机体的一个类似的生理病理过程，该过程涉及多种炎性细胞（中性粒细胞，单核一巨噬细胞，淋巴细胞等）和炎性介质，被称作全身炎性反应综合征（SIRS），乌司他丁是一种广谱的胰蛋白酶抑制剂，大量临床研究已证实它在感染，肿瘤，手术、休克等方面对心、肺、肝、脑、肾等脏器有很好的保护作用，现在认为这主要与其对全身炎性反应综合征的抑制有关。它可以下调促炎性因子-TNF-α，IL-1，IL-6，IL-8及核因子-KB、黏附分子、C-反应蛋白，并同时上调抗炎性因子-IL-10，1L-4。减轻全身炎性反应，防止多脏器功能障碍综合征（MODS）的发生。

A variety of conditions, both infectious and non-infectious can induce a similar host pathophysiologic response, which is called systemic inflammatory response syndrome. It refers to many inflammatory cells（neutrophils, mononuclear phagocytes, lymphocytes, etc.）and cytokine or non-cytokine mediators. Ulinastatin is a wide protease inhibitor, which has shown to protect heart, lung, liver, brain, kidney and other organs in inflammation, tumor, operation, shock and many fields. It can inhibit pro-inflammatory cytokines-TNF-α,IL-1,IL-6,IL-8 and nuclear kappa B, adhesion molecules and CRP, meanwhile stimulates the release of anti-inflammatory cytokines-IL-10 and IL-4, thus suppresses a systemic inflammatory response and subsequently prevent multi-organ dysfunction.