病毒性肝炎患者周围血T淋巴细胞亚群测定的临床意义

Detection of Peripheral Blood T Lymphocyte Subsets and their Clinical Significance in Patients with Viral hepatitis

本文对１５０例甲、乙型病毒性肝炎患者、３０例慢性血吸虫病患者和１４０例正常人作周围血Ｔ淋巴细胞亚群、细胞膜表面免疫球蛋白（ＳｍＩｇ）和Ｅ玫瑰花结形成细胞（ＥＲＦＣ）等检测。其结果表明，急、慢性病毒性肝炎患者与正常人比较，除ＥＲＦＣ明显较低外，其周围血ＯＫＴ３、ＯＫＴ４、ＯＫＴ８和ＳｍＩｇ均明显增高，尤以急性乙肝患者和血清ＨＢＶ－ＤＮＡ及ＨＢｅＡｇ阳性者更为明显，ＯＫＴ４／ＯＫＴ８比值下降，与对照组比较均有显著性差异。说明乙肝患者的Ｔ淋巴细胞亚群的变化与病毒复制有关，提示细胞免疫参与了乙肝的发病过程。

The peripheral blood T lymphocyte subsets,surface,membrane immunoglobin (SmIg)and Erose formation cell(ERFC) were measured in 150 patients with viral hepatitis A or B,30 cases with schistomosis and 140 normal subjects.The results showed that the peripheral blood OKT3,OKT4,OKT8 and SmⅠg levels in acute or chronic hepatitis patients especially in acute hepatitis B and serum HBVDNA positive patients were higher significantly than those in normal controls,but ERFC levels and ratio of OKT4/OKT8 were obviously lower than those of normal controls.So,the changes of T lymphocyte subsets in hepatitis B patients were related to viral replication.The results indicated cellular immune participate in the progression of hepatitis B.