肺癌患者术前病理诊断的临床意义

Clinical significance of preoperatively pathological diagnosis of lung cancer

目的探讨外科治疗肺癌患者术前明确病理诊断的临床意义。方法回顾性分析2000年1月～2005年1月本科治疗585例肺癌的临床及病理资料。结果经术前病理检查确诊肺癌529例,占外科治疗肺癌患者的90.4%（529/585）;其中诊断小细胞肺癌62例,均给予2周期术前新辅助化疗,有效率82.3%（51/62）,4例达到组织学完全缓解（6.5%）。36例局部晚期非小细胞肺癌给予1～2周期新辅助化疗,有效率55.6%（20/36）。结论肺癌术前病理诊断是分期综合治疗的前提;明确病理诊断为局限期小细胞肺癌和局部晚期非小细胞肺癌是术前新辅助化疗的根本依据。

Objective To evaluate the clinical significance of preoperatively pathological diagnosis in the surgical management of lung cancer. Methods The clinical and pathological data of 585 patients with primary lung cancer from Jan, 2000 to Jan, 2005 were analyzed retrospectively. Results 529 cases were pathologically diagnosed before operation, which counted for 90.4% （529/585） of total patients surgically treated for the primary lung cancer. Neoadjuvant chemotherapy （NAC） for two cycles was given to 62 patients who were diagnosed as small cell lung cancer （SCLC） before operation, in which effective rate was 82.3% （51/62） and 4 patients histologically completely relieved （6. 5%）. One or two cycles of neoadjuvant chemotherapy were given to 36 patients with local ad vanced non small cell lung cancer （NSCLC）, in which effective rate was 55.6%（20/36）. Conclusion Preoperative pathological diagnosis is necessary for the staging and comprehensive treatment of lung cancer. Preoperative Neoadjuvant chemotherapy for localized SCLC and advanced local NSCLC is based on definitely pathological diagnosis.