女性冠心病人性激素及其受体的变化

THE CHANGE OF SEX HORMONE AND SEX HORMONE RECEPTORS IN FEMALE PATIENTS WITH CORONARY HEART DISEASE

目的探索女性冠心病（ｃｏｒｏｎａｒｙｈｅａｒｔｄｉｓｅａｓｅ，ＣＨＤ）患者性激素和性激素受体的关系。方法选测女性ＣＨＤ患者２８例和对照组３２例（绝经期前后各半）。采用放射配体结合法检测外周血白细胞上雌激素受体（ｅｓ－ｔｒｏｇｅｎｒｅｃｅｐｔｏｒ，ＥＲ）和雄激素受体；采用放免法检测雌二醇（Ｅ２）和睾酮（Ｔ）。结果发现绝经后组Ｅ２、Ｅ２／Ｔ、ＥＲ明显低于绝经前组（Ｐ＜０．０１）；ＣＨＤ组ＥＲ明显低于绝经后期（Ｐ＜０．０１）。结论女性ＣＨＤ的发生与ＥＲ减少有关。并提出解释雌激素对ＣＨＤ的发生和发展中的新观点。

objective To investigate the changes and relations between sexhormone and sex hormone receptors in female patients with coronary heartdisease(CHD).Methods Measurements of estrogen receptors and andrin receptors on WBC by redipligand binding assay of female patients (n=28) withcoronary heart disease and reference subjects (n=32) including premenopause and postmenopause each in half were carried out. So did oestradiol and testosterone with radioimmune method.Results Oesstradiol,oestradiol/testosterone (E2/T) ratio and estrgen receptors in postmenopausal groupwere apparently lower than those in premenopausal one (p<0.01).And theaverage estrogen receptor in CHD group was apparently lower than those in postmenopausal one (p<0.01).Conclusion These results indicated thatthe occurrence of CHD in female patients might be related to the reduction of estrogen receptors; a new view of how to explain the effects ofestrogen on the occurrence and development of coronary heart disease wasproposed.