银屑病患者血甘油三酯与胆固醇水平的探讨

A STUDY OF SERUM TRIGLYCERIDES AND CHOLESTEROL LEVEL OF 31 CASES OF PSORIASIS PATIENTS

目的探讨银屑病患者血甘油三酯与胆固醇水平的改变在发病中的意义。方法采用酶法和免疫透射比浊法测定３１例银屑病患者（男性２２例，女性９例）血清总胆固醇，甘油三酯、高密度脂蛋白胆固醇、载脂蛋白ＡＩ、载脂蛋白Ｂ－１００、及ＡＩ／Ｂ－１００水平。结果显示甘油三酯高于正常（Ｐ＜０．０１）。载脂蛋白Ｂ－１００高于正常（Ｐ＜０．０５）。总胆固醇、高密度脂蛋白胆固醇、载脂蛋白ＡＩ、ＡＩ／Ｂ－１００与正常比较差异皆不显著（Ｐ＜０．０５）。结论血清中内源性甘油三酯升高及其代谢可能对银屑病的诱发及加剧有一定影响。

Objective To study the influence of serum triglycerides and cholesterol on pathogenesis of psoriasis.Methods Serum levels of total cholesterol(Chol),triglycerides(Trig),highdensitylipoprotein cholesterol(HDLC),apolipoprotein AI (Apo AI),apolipoprotein B100 (Apo B100) and AI/B100 of 31 cases of psoriasis patients were determined by enyme and ITA methods.Results It was showed that Trig was significantly higher than that of normal controls(P<0.01).Apo B100 was also significantly higher than that of normal controls (P<0.05).Chol,HDLC,Apo AI contents and Apo AI/Apo B100 were normal.Conclusion It was proposed that the higher level of endogenous serum Trig and its abnormal metabolism might have some influence on the occurrance and severity of psoriasis.