摘要
目的通过检测服用丙戊酸钠癫患儿血糖及血清胰岛素水平,观察丙戊酸钠对癫患儿血糖及血清胰岛素的影响。方法采用葡萄糖氧化酶法测定葡萄糖浓度,采用放射免疫分析法测定胰岛素浓度。结果丙戊酸钠治疗3个月、6个月时癫患儿的血清胰岛素、胰岛素抵抗指数较治疗前均明显增高(P<0.05),治疗3个月时和6个月时相比差异无统计学意义(P>0.05),但血糖无明显变化(P>0.05)。结论丙戊酸钠不引起癫患儿血糖明显变化,但血清胰岛素明显增加。
Objective To obtain the affection of sodium valproate to blood glucose and serum insulinum in chidren with epilepsy by detecting the level of blood glucose and serum insulinum in children with epilepsy. Methods Glucose oxidase method was adopted to detect the concentration of blood glucose, and radio immunoassays method was used to detect serum insulinum. Results The serum insulinum and insulin resistance indexes of children with epilepsy were significant higher than before, after taking sodium valproate 3 months, 6 months（P〈0. 05）. There was no significance between taking sodium valproate 3 months, 6 months （P〈0.05）. Conclusion Sodium valproate doesn＇t cause blood glucose to change significantly, but serum insulinum raises significantly.
出处
《中国实用神经疾病杂志》
2008年第5期9-11,共3页
Chinese Journal of Practical Nervous Diseases
关键词
血清胰岛素
丙戊酸钠
血糖
癫痫
儿童
Serum insulinum
Sodium valproate
Blood glucose
Epilepsy
Children
