肺癌间质内肥大细胞定量计数与临床病理的研究

Clinicopathological Significance of Quantitative Determination of Interstitial Mast Cells in Lung Cancer Tissue

对199例经手术切除的原发性肺癌间质内肥大细胞进行了定量计数，结果发现：肺腺癌内肥大细胞数高于鳞癌及小细胞癌（P＜0．05，P＜0.02），鳞癌Ⅰ、Ⅱ组肥大细胞数高于Ⅲ级（P＜0．02），肺腺癌中细支气管一肺泡癌肥大细胞计数明显高于其它类型（P＜0．02，P＜0．02，P＜0．01）。肺鳞癌及腺癌的肥大细胞数在D《3cm组均高于D≥5cm组（P＜0．02，P＜0．05），肺鳞癌半年内死亡组的肥大细胞数明显低于5年以上生存组（P＜0．01），提示其与肺癌组织学类型、细胞分化、肿瘤生长有关，且对预后判定有一定意义。

Interstitial mast cell count was taken in the operative specimen of 199 patients with lung cancer. The results revealed that the number of mast cells in adenocarcinoma was higher than those in the squamous cell or small cell carcinomas (P<0.05, P<0.02). The mast cells counts in the grade I or II squamous cell carcinoma were higher than that in the grade III cancer (P<0.02), and that they were obviously higher in the bronchioalveolar carcinoma than in other cancer types (P<0.02, P<0. 02, P<0. 01). The amount of mast cells in the squamous cell carcinoma or adenocarcinoma was in inverse ratio to the size of cancer. The more the mast cells were found,the longer the survival of the patient was. In conclusion, quantitative determination of interstitlal mast cells might reflect the histological type, cellular differentiation, growth and prognosis of the lung cancer.