同种异体肾上腺移植的实验研究

An experimental study on allograft of adrenal in rats

Ｗｉｓｔａｒ大鼠行双侧肾上腺切除，将一枚异体新生鼠肾上腺植入右侧肾被膜下，观察移植后的肾上腺组织学和血清中ＡＣＴＨ含量的变化。结果：移植后１周，植入的肾上腺变性，中央坏死，囊下细胞再生。移植后７周，皮质分化成球状带、束状带和网状带并具有分泌功能。移植后鼠血清中ＡＣＴＨ逐渐升高，在移植后第５周达高峰，第７周显著下降。结论：在同种肾上腺移植中，新生鼠肾上腺是理想的移植物。

? The changes of the adrenal histology and the serum ACTH contents were studied in the rats which were bilaterally adrenalectomized and grafted with neonatal adrenal.The results demonstrated that 1 week after transplantation,the denaturation,central necrosis and subcapsulcell regeneration occurred in the transplants,which differentiated into the zona glomerulus,zona fasciculata and zona reticularis,and that 7 weeks after transplantation,the serum ACTH increased gradually, and decreased when the cortical cells became mature,indicating that the transplanted adrenal undergoes a development process similar to that of the newborn rat adrenal and ACTH secreted by the hypophysis is very important to the maturation of the adrenal.It is concluded that the adrenal of the newborns is an ideal transplants for allograft.