脑脊液前白蛋白与酶水平在中枢神经系统感染疾病中的变化

Chang of CSF prealbumin and four kinds of enzymes in infection of central nervous system

为探讨化脓性、结核性、病毒性脑膜炎患者脑脊液（ＣＳＦ）中前白蛋白（ＰＡ）、Ｎ乙酰βＤ氨基葡萄糖苷酶（ＮＡＧ）、肌酸激酶Ｂ亚基（ＣＫＢ亚基）、谷草转氨酶（ＡＳＴ）与乳酸脱氢酶（ＬＤ）５种成分的变化规律，用常规方法测定以上５种指标的含量。结果：３组患者ＣＳＦ中ＰＡ明显低于对照组；ＮＡＧ、ＣＫＢ亚基与ＬＤ活性显著增高，以化脓性脑膜炎改变最显著；除ＬＤ、ＡＳＴ外其他指标在结核性脑膜炎与病毒性脑膜炎间无明显差异；ＡＳＴ活性高于对照组，且化脓性脑膜炎＞病毒性脑膜炎＞结核性脑膜炎。结论：测定ＣＳＦ中５种成分对鉴别３种脑膜炎有一定临床价值；每组患者ＣＳＦ中５种成分含量的改变无相关关系，可能与发病机制、疾病部位与严重程度及此物质在脑内分布特点、异常代谢不同有关。

To investigate the changes of CSF levels of prealbumin(PA),aspartate aminotransferase(AST),creatine kinaseB(CKB subunit),NacetylβDglucosaminidase(NAG)and lactate dehydroganase(LD)in patients with purulent,tuberculous and viral meningitis and their clinical significence,they were assayed.Although CSF PA markedly decreased in three groups of the patients,NAG,CKB subunit,AST and LD significantly increased in all patients.The changes of all 5 components in purulent meningitis were much more than those in other two diseases.AST activity was higher,and LD activity lower in viral meningitis than that in tuberculous meningitis,The measurements of the 5 components in CSF were useful for differential diagnosis of three kinds of meningitis.