水介质中三组分一锅合成1-芳基苯并[f]喹啉衍生物

Three-Component One-Pot Synthesis of 1-Aryl-4-benzo[f]quinoline Derivatives in Aqueous Media

以芳醛、2-萘胺和Meldrum酸为原料,以水为溶剂,在回流条件下以三乙基苄基氯化铵为催化剂通过三组分一锅反应,合成了一系列的1-芳基苯并[f]喹啉衍生物.该方法具有反应条件温和、产率较高(79%～87%)、环境友好等优点.产物的结构通过熔点,IR,1H NMR和元素分析表征.

A series of 1-aryl-1,2-dihydrobenzo[f]quinolin-3（4H）-one derivatives were synthesized by a three-component one-pot reaction of benzaldehyde, naphthalene-2-amine and meldrum＇s acid at refluxing temperature catalyzed by triethylbenzylammonium chloride in water. This method has the advantages of milder reaction conditions, good yields （79%-87%） and environmental benignity. The structures of the products were characterized by melting points, IR, ^1H NMR spectra and elemental analysis.