1GUNSALUS I C, LPEDERSON T C ,SLIGAR S G. Oxygenase-catalyzed biological hydroxylations[J]. Annual Review of Biochemistry, 1975 ,44 (1) :377-407.
2ORTIS de MONTELLA NO P R. Cytochrome P450 : Structure, Mechanism, and Biochemistry[M]. 2nd ed. New York : Plenum, 1995.
3PORTER T D, COON MJ. CytoehromeP450: Multiplicity of isoforms, substrates, and catalytic and regulatory mechanism[J].Journal of Biology Chemistry, 1991,266(21) : 13459-13472.
4WEN L P, FULCO A 1. Cloning of the gene encoding a catalytically self-sufficient cytochrome P- 450 fatty acid monooxygenase induced by barbiturates in Bacillus megaterium and its functional expression and regulation in heterologous (Escherichia coli) and homologous (Bacillus megaterium) hosts[J].Journal of Biological Chemistry, 1987 ,262 ( 14) :6676-6682.
5BELL S G, HARDORD-CROSS C F, WONG L L. Engineering the CYPIOI system for in vivo oxidation of unnatural substrates[J]. Protein Engineering, 200 1 , 14 ( 10) : 797 -802.
6SCHEW H, KAUP B A, SCHRADERJ. Improvement of P450BM-3 whole-cell biocatalysis by integrating heterologous cofactor regeneration combining glucose facilitator and dehydrogenase in E. coli[J]. Applied Microbiology and Biotechnology ,2008,78 (1) :55-65.
7CANMEHAEL A B, WONG L L. Protein engineering of Bacillus megaterium CYPI02 : The Oxidation of Polycyclic aromatic hydrocarbons[J]. EuropeanJournal of Biochemistry,2001 ,268( 10) :3117-3125.
8SCHNEIDER S, WUBBOLTS M G, SANGLARD D, et al. Production of chiral hydroxyl long chain fatty acids by whole cell biocatalysis of pentadecanoic acid with an E. coli recombinant containing cytochrome P450 BM-3 monooxygenase[J]. Tetrahedron: Asymmetry, 1998,16 (9) : 2832-2844.
9LI Q S, SCHW ANEBERG U, SCHMID R D. Directed evolution of the fatty-acid hydroxylase P450 BM-3 into an indolc-hydroxylating catalyst [J]. Chemistry ,2000 ,6( 9) : 1531-1536.
10SCHWEDE T ,KOPPJ, GUEX N ,et al. Swiss-Model: An automated protein homology-modeling server[J]. Nucleic Acids Research ,2003 ,31 (13) :3381-3385.