西酞普兰治疗老年抑郁症的对照研究

A comparative study of cital opram in the treatment of elderly depressive

目的:比较西酞普兰与丙米嗪治疗老年抑郁症的疗效及安全性。方法:将72例老年抑郁症患者随机分成两组。其中,研究组36例,应用西酞普兰治疗;对照组36例,应用丙米嗪治疗;疗程均为6周。采用汉密尔顿抑郁量表,临床疗效总评定量表评定临床疗效,副反应量表、评定药物的不良反应。结果:两组总体疗效相当(P>0.05),但西酞普兰组不良反应较丙米嗪组发生率低。结论:西酞普兰治疗老年抑郁症疗效显著,不良反应少,安全性高。

Objective： To compare curative effects and safety of citalopram and imipramine in the treatment of elderly depressive patients. Methods：72 patients with depression were randomly divided into study （n = 36,citalopram） and control group（n = 36,imipramine） for 6 weeks. Clinical curative effects were assessed with the Hamilton Depression Scale（HAMD） and Clinical Global Impression（CGI） and side effects wirt the Treatment Emergent Symptom Scale （TESS）. l^esults： There was no signifivant difference in global curative effect between the two groups（P 〉 0.05）, citalopram took effect quicker, its side ettects was milider. Conclusion： Citalopram has significant curative efficacy, milder adverse reactions and higher safety in the treatment of geriatric depression.