糖耐量低减患者的血管内皮生长因子及血清C反应蛋白水平分析

Analysis of serum levels of vascular endothelial growth factor and C-reactive protein in patients with impaired glucose tolerance

目的探讨糖耐量低减患者血管内皮生长因子、血清C反应蛋白水平的变化。方法口服75 g葡萄糖耐量试验筛查出糖耐量低减患者61例和糖耐量正常的体检健康者30例,测定两组人群血清内皮生长因子、血清C反应蛋白水平。结果糖耐量低减组血管内皮生长因子、血清C反应蛋白水平均高于糖耐量正常组(P<0.01)。结论在糖耐量低减阶段,患者血管内皮生长因子、血清C反应蛋白已开始升高,提示糖耐量低减人群具备了发生血管并发症的危险。

Objective To investigate changes of serum levels of vascular endothelial growth factor （VEGF） and C-reactive protein （CRP） in patients with impaired glucose tolerance （IGT）. Methods 61 patients with IGT （patient group） and 30 controls with normal glucose tolerance （NGT） （control group） diagnosed by oral glucose tolerance test （OGTT） were involved in the investigation. Serum levels of vascular endothelial growth factor （VEGF） and C-reactive protein （CRP） were measured for the two groups. Results The serum levels of VEGF and CRP in patients with IGT were both significantly higher than those in controls （P〈0. 01）. Conclusion In the stage of impaired glucose tolerance, serum levels of VEGF and CRP begin to rise, indicating the population with IGT are susceptible to vascular complications.