非霍奇金淋巴瘤VEGF表达与临床特征的关系初探

Correlation Between VEGF Expression and Clinical Characteristic of Patient with Non-Hodgkin’s Lymphoma:an Initial Study

目的研究非霍奇金淋巴瘤血管内皮生长因子(VEGF)表达与患者性别、年龄、疾病恶性程度、临床分期、B症状及首程化疗完全缓解(CR)率的关系。方法采用LSAB法对98例非霍奇金淋巴瘤病理标本进行VEGF免疫组化染色,通过χ2检验分别分析肿瘤组织VEGF表达与各临床特征的关系。结果对不同性别、年龄、疾病恶性程度、临床期别的VEGF阳性率进行比较,差异均无统计学意义。而伴有B症状的病例其VEGF阳性率为86.1%,无B症状病例为51.6%,两者比较差异有统计学意义(P=0.001)。在可评价疗效的94例患者中,按B症状有无进行分层,比较VEGF阳性组与阴性组化疗后的CR率(无B症状:19.4%vs70.4%,P=0.000;有B症状:29.0%vs80.0%,P=0.028),差异均有统计学意义。结论非霍奇金淋巴瘤VEGF表达与患者的性别、年龄、疾病恶性程度及分期等临床特征无关,而与伴有B症状和首程化疗后的低CR率有关。

Objective To study whether VEGF expression is associated with clinical characteristics such as gender, age, aggressive, stage, B-symptoms and complete remission （CR） rate of patients with non-Hodgkin＇ s lymphoma. Methods Expression of VEGF had been tested in 98 biopsy samples by immunohistochemical method as LSAB. Chi-Square test was used to do the statistical analysis of ratio comparison between different groups. Results Comparing VEGF positive rates grouped by sexuality, age, aggressive grade or stage, the results suggested no significant correlation between them. VEGF positive rate of patients accompanied with B-symptoms was 86. 1%, versus 51. 6% of patients B-symptoms free, P= 0. 001. Among 94 patients, their responses to chemotherapy could be estimated, delaminated by B-symptoms, and the CR rate of VEGF negative group was significantly higher, P values were 0. 000 and 0. 028. Conclusions Expression of VEGF is associated with B- symptoms and poor response to chemotherapy in patients with non-Hodgkin＇s lymphoma, there was not any relationship to have been found between VEGF expression and sexuality, age, aggressive grade, stage.