期刊文献+

淋巴毒素α基因多态性与冠心病 被引量:3

下载PDF
导出
摘要 淋巴毒素α(LT-α)是肿瘤坏死因子家族的主要成员,其主要功能是介导炎症免疫反应,从而影响细胞坏死、分化。目前,LT-α的功能、遗传差异及与冠心病的关系已成为当前心血管疾病研究的一个热点。本文阐述了LT-α的生物学特性、功能及LT-α基因多态性与冠心病的关系。
作者 高涵翔 张钲
出处 《国际心血管病杂志》 2008年第3期138-140,共3页 International Journal of Cardiovascular Disease
  • 相关文献

参考文献14

  • 1[1]Talmud PJ.Gene-environment interaction and its impact on coronary heart disease risk[J].Nutr Metab Cardiovase DiS,2007,17(2):148-152.
  • 2[2]Ware CF.Network communications:lymphotoxins,LIGHT,and TNF[J].Annu Rev Immunol,2005,23:787-819.
  • 3[3]Spahn TW,Eugster HP,Fontana A,et al.Role of lymphotoxin in experimental models of infectious diseases:potential benefits and risks of a therapeutic inhibition of the 1ymphotoxin-beta receptor pathway[J].Infect Immun,2005,73(11):7077-7088.
  • 4[4]Ozaki K,Inoue K,Sato H,et al.Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro[J].Nature,2004,429(6987):72-75.
  • 5[5]Ozaki K,Ohnishi Y.Iida A,et al.Functional SNPs in the 1ymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction[J].Nat Genet,2002,32(4):650-654.
  • 6[6]Mizuno H,Sato H,Sakata Y,et al.Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction[J].Atheroselerosis,2006,185(2):400-405.
  • 7[7]PROCARDIS Consortium.A trio family study showing association of the lymphotoxin-alpha N26(804A)allele with coronary artery disease[J].Eur J Hum Genet,2004,12(9):770-774.
  • 8[8]Laxton R,Pearce E,Kyriakou T,et al.Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary athcrosclcrosis[J].Genes Immun,2005,6(6):539-541.
  • 9[9]Suzuki G,Izumi S,Hakoda M,et al.LTA 252(;allelecontaining haplotype block is associated with high serum C-reactive protein levels[J].Atherosclerosis,2004,176 (1):91-94.
  • 10[10]Kimura A,Takahashi M,Choi BY,et al.Lack of assoeiation between LTA and I.GALS2 polymorphisms and myocardial infarction in Japanese and Korean populations[J].Tissue Antigens,2007,69(3):265-269.

同被引文献12

  • 1赵水平 曾令辉.慢性心力衰竭与血浆肿瘤坏死因子(摘要)[J].中华心血管病杂志,1997,25(4):304-304.
  • 2Ozaki K,Ohnishi Y,Iida A,et al.Functional SNPs in the lymphotoxin-alpha gene that associated with susceptibility to myocardial infarction[J].Nat Genet,2002,32(4):650-654.
  • 3Blum A,Miller H.Pathophysiology role of cytokines in congestive heart failure[J].Annual Review of Medicine,2001,52:15-27.
  • 4Li YY,Feng YQ,Kadokami T,et al.Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(23):12746-12751.
  • 5Meigs JB,Hu FB,Rifai N,et al.Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus[J].JAMA,2004,291:1978-1986.
  • 6Asselbergs FW,Pai JK,Rexrode KM,et al.Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers,cellular adhesion molecules and risk of coronary heart disease[J].Clin Sci(Lond),2007,112(5):291-298.
  • 7Pasic, JagodMD. Cytokines in depression and heart failure [ J]. Psychosconm Med,2003,65 : 181 - 190.
  • 8Ozaki, OhnishiY, Lida A,et al. Functional SNPs in the lym- pho-toxin-alpha gene that associated with susceptibility to myocardial in- farction [ J ]. Nat Genet, 2002,32 ( 4 ) : 650- 654.
  • 9Paulus WJ. Cytokines and heart failure [ J ]. Heart Fail Monit,2000,1 (2) :50-56.
  • 10刘同涛,田庆印,程庆峨,张召平,贾立华.充血性心力衰竭患者血清肿瘤坏死因子、白介素-6及其受体水平的研究[J].山东医科大学学报,1998,36(3):230-232. 被引量:4

引证文献3

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部