胚胎干细胞的定向心肌分化及调控
摘要
胚胎干细胞是具有分化为三个胚层来源的各种类型组织细胞潜能的多能干细胞,可在体外无限增殖。信号分子、化学诱导剂、激素和细胞内转录因子可诱导和调控胚胎干细胞进行心肌细胞分化,为干细胞移植用于心肌再生和改善心功能提供了潜在的细胞来源。
出处
《国际心血管病杂志》
2008年第3期150-153,共4页
International Journal of Cardiovascular Disease
参考文献20
-
1[1]Wei H,Juhasz O,Li J,et al.Embryonic stem cells and cardiomyocyte differentiation:phenotypic and molecular analyses[J].J Cell Mol Med,2005,9(4):804-817.
-
2[2]Snir M,Kehat I,Gepstein A,et al.Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes.Am J Physiol Heart Circ Physiol,2003,285(6):H2355-H2363.
-
3[3]Koyanagi M,Haendeler J,Badorff C,et al.Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells[J].J Biol Chem,2005,280(17):16838-16842.
-
4[4]Yamashita JK,Takano M,Hiraoka-Kanie M,et al.Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction[J].FASEB J,2005,19(11):1534-1536.
-
5[5]Singh AM,Li FQ,Hamazaki T,et al.Chibby,an antagonist of the Wnt/beta-catenin pathway,facilitates cardio myocyte differentiation of murine embryonic stem cells[J].Circulation,2007,115(5):617-626.
-
6[6]Terami H,Hidaka K,Katsumata T,et al.Wntll facilitates embryonic stem eell differentiation to Nkx2.5-positive cardiomyocytes[J].Biochem Biophys Res Commun,2004,325(3):968-975.
-
7[7]Maye P,Zheng J,Li L,et al.Multiple mechanisms for Wnt 11 mediated repression of the canonical Wnt signaling pathway[J].J Biol Chem,2004,279(23):24659-24665,
-
8[8]Keller G.Embryonic stem cell differentiation:emergence of a new era in biology and medicine[J].Genes Dev,2005,19(10):1129-1155.
-
9[9]Taha MF,Valojerdi MR,Mowla SJ.Effect of bone morphogenetic protein-4(BMP-4)on cardiomyocyte differentiation from mouse embryonic stem cell[J].Int J Cardiol,2007.120(1).92 101.
-
10[10]Yuasa S,Itabashi Y,Koshimizu U,et al.Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells[J].Nat Biotechnol,2005,23(5):607-611.
-
1张萍,汤永红.组蛋白去乙酰化酶参与调控神经干细胞分化的研究进展[J].中国现代医药杂志,2014,16(11):110-112.
-
2本期专题:干细胞与微环境[J].中国组织工程研究,2012,16(6):1114-1114.
-
3刘红敏,陈旭东,华新宇.体外诱导人羊膜上皮细胞分化为神经样细胞[J].中国实验诊断学,2011,15(10):1622-1624.
-
4何学令,姚晓玲,冯贤,邱飞远,李凯,吴江,李良.力学刺激和成骨化学诱导剂对大鼠骨髓间充质干细胞成骨分化能力的影响[J].医用生物力学,2011,26(2):116-120. 被引量:14
-
5张卫泽,樊艳,陈永清,马凌,秦勉,哈小琴,韩娟萍.血管紧张素Ⅱ对成人脂肪间充质干细胞向心肌细胞分化的影响[J].第四军医大学学报,2008,29(8):692-695. 被引量:13
-
6于丽,张华芳,张炳强,张雪莉,管英俊.体外不同诱导条件对人脐血间充质干细胞分化为神经细胞的研究[J].中华老年心脑血管病杂志,2009,11(8):617-620. 被引量:1
-
7潘廷明,徐皓,陈建梅.骨髓间充质干细胞向神经样细胞诱导分化的影响因素[J].医学综述,2009,15(1):31-33.
-
8运晨霞,郭宏伟,邓家刚,兰太进,杨柯.芒果苷对2215细胞MAPK信号通路的影响[J].细胞与分子免疫学杂志,2011,27(8):915-917. 被引量:6
-
9高梅,孙杰,金文杰,钱燕宁.氯胺酮对离体人辅助T细胞分化的影响[J].南京医科大学学报(自然科学版),2011,31(12):1741-1747.
-
10王莹,赵洪昌,赵文静,叶冬霞,李晶,罗速.人骨髓间充质干细胞体外定向诱导分化为神经元样细胞[J].中国组织工程研究与临床康复,2010,14(49):9138-9141. 被引量:1