中国在消灭脊髓灰质炎(脊灰)后期使用赛宾株-脊灰灭活疫苗替代口服脊灰减毒活疫苗策略的前瞻性分析

Prospective Analysis on Strategy of OPV Switching to Sabin-IPV at the Endgame of Poliomyelitis Eradication in China

目的探讨中国在消灭脊髓灰质炎(脊灰)后期的免疫策略。方法运用循证医学的方法,检索国内外研究资料,调查中国脊灰疫苗生产和使用现状,从免疫策略比较赛宾株-脊灰灭活疫苗(Sabin-Inactivated Poliovirus Vac-cine,sIPV)替代口服脊灰减毒活疫苗(Oral Poliomyelitis Live Vaccine,OPV)的可行性,并从免疫程序等方面进行前瞻性综合分析。结果中国应考虑选择以IPV替代OPV的免疫策略,且国产sIPV即将问世,在政策、技术、疫苗供应和其它保障方面均具备了替代的条件,常规免疫可参照目前OPV免疫程序。结论中国应进一步加强消灭脊灰后期免疫策略的研究,积极做好sIPV替代OPV的准备工作。

Objective To explore the immunization strategy at the endgame of poliomyelitis eradication in China. Methods To search the related study databases by the mean of evidence based medicine,and to investigate the update status of production and usage of polio vaccine in China. The general prospective analysis was conducted on aspects of the comparison of different immunization strategies, the feasibility of oral poliovirus vaccine （OPV）switching to Sabin strain inactivated poliovirus vaccine （Sabin-IPV）and the Sabin-IPV immunization schedule. Results The immunization strategy of OPV switching to IPV should be considered to choose in China because the domestic Sabin-IPV products will be registered soon and the switching feasibility is already provided with the conditions of police, technique, vaccine supply, and other guarantee. The routine immunization of Sabin-IPV can be carried out referring to the update OPV immunization schedule. Conclusion The study on immunization strategy at the endgame of poliomyelitis eradication should be further enhanced and the preparation of OPV switching Sabin-IPV should be considered in China.