Sigma B因子活性的调节及其在几种革兰氏阳性食源性致病菌中的作用

The regulation of σ^B activity and its role in some gram-positive food-borne pathogens——A review

SigmaB(σB)是许多革兰氏阳性菌对环境胁迫产生应答反应的主要调控因子。不仅在芽孢形成中具有重要作用,而且σB也直接或间接地调控包括蜡样芽孢杆菌(Bacillus cereus)、单核细胞增生李斯特菌(Listeria monocytogenes)和金黄色葡萄球菌(Staphylococcus aureus)在内的一些革兰氏阳性食源性致病菌毒力及毒力相关基因的表达。本文结合作者在国内外的相关工作,综述了σB活性的调节方式及其在上述革兰氏阳性食源性致病菌中相关作用的最新研究进展,为深入研究革兰氏阳性食源性致病菌的致病机理、预防和治疗细菌感染提供新的思路和理论依据。

The alternative sigma factor os modulates the stress response of several Gram-positive bacteria. Not only does σ^B play a prominent role in sporulation in the Gram-positive model organism Bacillus subtilis, but it also contributes both directly and indirectly to bacterial virulence in the food-borne human pathogens Bacillus cereus, Listeria monocytogenes and Staphylococcus aureus. As σ^B has been shown to regulate expression of both virulence and virulence-associated genes, it indicates that σ^B is a key player in pathogen ecopbysiology.