门冬氨酸鸟氨酸对急性中毒性肝损伤的保护作用

Protective effect of L - Ornithine - L - Aspartate against hepatic injury in patients with acute poisoning

目的利用门冬氨酸鸟氨酸对临床急性中毒性肝损伤进行治疗，评价其在肝损伤治疗中对肝脏的保护作用。方法将95例临床中毒性肝损伤患者随机分为治疗组（50例）和对照组（45例），治疗组在常规综合治疗的基础上将门冬氨酸鸟氨酸10g加入10％葡萄糖溶液250ml静脉滴注，1次／d，7d为一疗程。结果门冬氨酸鸟氨酸可明显降低患者转氨酶，改善肝功能（P〈0．05或0．01），治疗中毒性肝损伤临床疗效显著优于对照纽（P〈0．05），且无明显不良反应。结论门冬氨酸鸟氨酸是治疗中毒性肝损伤的有效药物，有临床推广应用价值。

Objective To observe the protective effect of L- Ornithine -L- Aspartate against hepatic injury in patients with acute poisoning. Methods 95 patients with hepatic injury caused by acute poisoning were divided into therapy group （ n = 50） and control group （ n = 45 ）. Patients in the control group were treated with routine comprehensive theray, and those in the therapy group received additional intravenous administration with 10. 0 gram L- Ornithine- L- Aspartate in 250 ml 10% glucose（ once daily ,7 days for a treatment course）. Results L - Ornithine - L - Aspartate improved hepatic function （ P 〈 0.05 or 0.01 ）, and no sig- nificant side effect was observed in of L - Ornithine - L - Aspartate treatment. Conclusion L - Ornithine - L -Aspartate has the protective effect against hepatic injury in patients with acute poisoning.