急性病毒性肝炎患者C-反应蛋白测定的临床意义

The level of CRP in acute viral hepatitis patients and its clinical significance

目的探讨急性病毒性肝炎患者血清C-反应蛋白（CRP）的变化及其临床意义。方法选择68例急性病毒性肝炎患者及75例健康体检者作为对照组，采用免疫比浊法Bayer ADVIA 1650全自动生化分析仪测定血清CRP含量及肝功能指标。采用PEMS3．1统计软件，t或t’检验分析数据。结果急性病毒性肝炎患者急性期时，血清CRP（11．2±5．6）mg／L和丙氨酸氨基转移酶（ALT）（920±116）U／L均明显升高，分别与对照组CRP（2．8±21）mg／L和ALT（〉40U／L）相比，差异有统计学意义（P〈0．05）；急性病毒性肝炎患者恢复期，血清CRP（4．0±4．8）mg／L和ALT（〈40U／L）均明显下降，与急性期时水平相比，差异有统计学意义（P〈0．05），与对照组相比，差异无统计学意义（P〉0．05）。结论急性病毒性肝炎患者血清CRP变化与病情相关，也与AIT水平呈正相关，对急性病毒性肝炎的病情监测有一定临床指导意义。

Objective To study the clinical significance and the level of CRP in acute viral hepatitis patients. Methods The level of CRP in serum was dynamic detected for 68 patients with acute viral hepatitis patients and 75 healthy persons as a control group by immunoturbjdimetry on Bayer ADVIA 1650 automatic biochemistry analyzer. Results In acute stage of the acute viral hepatitis patients group,the level of CRP（11. 2 ±5. 6）mg/L and ALT （920 ＋116） （U/L） in serum were both higher than that of the control group with CRP （2.8 ±2. 1 ）mg/L and ALT （ 〉40 U/L）,significantly. There had significant statistical differences between the two groups （ P 〈0.05）,respectively;In restoration stage of the acute viral hepatitis patients group,the level of CRP （4. 0±4. 8）mg/L and ALT （ 〈40 U/L）in serum were both significantly decreased, compared to that of the levels in the acute stage. The differences were significant （ P 〈0.05）. And compared to the control group, there was no significant difference between them （ P 〉0.05）. Conclusion The results demonstrate that the level of CRP associate with the disease, and positively correlate with the level of ALT in serum in the acute viral hepatitis patients. There is some clinical significance on monitoring pathogenetic condition of acute viral hepatitis.