纳米球/微球包埋维生素A和维生素E

Study on vitamins A and E encapsulated by nanoparticles/microparticles system

研究了一种可分步释放多组分的包埋体系,即包埋VA的疏水性纳米球与VE同时被包埋在对湿度敏感的微球体系中。采用单甘酯为纳米球壁材包埋VA,辛烯基琥珀酸酯化淀粉(HI-CAP100)为外层微球壁材包埋VE。由热均质-喷雾干燥法制备纳米球/微球包埋体系,通过单因素、正交实验确定了包埋VA、VE多组分包埋体系的最佳配方和喷雾干燥工艺条件:两种壁材辛烯基琥珀酸酯化淀粉与单甘酯的质量比为8∶1(w/w),芯材VA的载量为25%(w/w),微球芯材VE和纳米球占微球壁材辛烯基琥珀酸酯化淀粉的百分比为50%(w/w),固形物含量为40%(w/w);喷雾工艺条件为进风温度185℃,出风温度80℃,均质压力40MPa。

A multi-component encapsulation system providing release step by step which was nanoparticled enclosing VA encapsulated with VE in moisture sensitive microparticles was studied, The VA was encapsulated by glycerin monostearate which as wall material of nanoparticle while VE was encapsulated by starch octenylsuccinate （HI-CAP100） as the wall material of microparticles. The system was made by hot homogenization-spray drying technique and the optimum formulation of this multi-component encapsulation system and the best spray drying condition was determined by single-factor experiment and orthogonal experiment. The results showed that the best formulation was the proportion between starch octenylsuccinate and glycerin monostearate was 8：1 （w/w） the capacity of VA was 25% （w/w）, the percent of VE, anoparticles in wall material of microparticle starch octenylsuccinate was 50% （w/w）, solid content was 40% （w/w）, the optimum spray drying parameters were as follows： the inlet air temperature was around 185℃,the outlet air temperature was around 80℃, the homogenizing pressure was 40MPa.