过氧化物酶体增殖物活化受体γ(PPAR γ)与肝癌瘤内微循环的关系(英文)

Peroxisome proliferator-activated receptorγexpression correlates with tumor angiogenesis in human hepatocellular carcinoma

观察 peroxisome 的表示的协会的目的有微容器密度(MVD ) 和在肝细胞癌(HCC ) 的血管形成模仿(VM ) 的激活 proliferator 的受体 γ (PPARγ) 并且探索他们的临床的意义。PPARγ 和 MVD 和 VM 的表情被 CD34 免疫测试的方法组织化学(IHC ) 染色并且在 HCC 纸巾和它的配对的非癌的纸巾的 34 种情况中的周期的 acid-Schiff (舞步) 反应。他们的生物行为被分析并且与 clinicopathological 特征联系了。结果 PPARγ 是过去表示的(24/34 ) 在 HCC 纸巾。它与肿瘤尺寸被联系(】 5 厘米， P = 0.027 ) ，破囊(P = 0.014 ) ，趋势到转移和复发(P = 0.001 ) 。MVD 更高(23/24 ) 在 HCC 纸巾比那在相应帕拉癌的纸巾(t = 18.925， P 【 0.05 ) 。在 PPARγ 和高 MVD 的在表示上之间有重要积极关联(r = 0.519 ) 。Kaplan-Meier 分析显示 PPARγ 和 VM 和高 MVD 的那积极表情能被用于建立 HCC 病人的幸存率(P = 0.013， 0.036 和 0.022 分别地；木头等级测试) 。考克斯危险模型分析显示出那积极 PPARγ 表情，高 MVD 是为 HCC 的独立预示的因素。PPARγ 与发展相关的结论微在 HCC 循环。PPARγ 是为 HCC 评估的新奇预示的指示物。

Objective： To observe the association of the expression of peroxisome proliferator-activated receptor y （PPARy） with microvessel density （MVD） and vascularization mimicry （VM） in hepatocellular carcinoma （HCC） and explore their clinical significance. Methods： The expressions of PPARy and MVD and VM were tested by CD34 immunohistochemical （IHC） staining and periodic acid-Schiff （PAS） reaction in 34 cases of HCC tissues and its paired non-cancerous tissues. Their biological behaviors were analyzed and associated with the clinicopathological features. Results： PPARy was over-expressed （24/34） in HCC tissues, it was associated with tumor size （〉 5 cm, P = 0.027）, broken capsule （P = 0.014）, tendency to metastasis and recurrence （P = 0.001）. The MVD was higher （23/24） in HCC tissues than that in corresponding para-cancerous tissues （t = 18.925, P 〈 0.05）. There was a significant positive correlation between the over-expression of PPARy and high MVD （r = 0.519）. Kaplan-Meier analysis indicated that positive expression of PPARy and VM and high MVD could be used for predicating the survival rate of HCC patients （P = 0.013, 0.036 and 0.022, respectively; log-rank test）. Cox hazard model analysis showed that positive PPARy expression and high MVD were the independent prognostic factors for HCC. Conclusion： The PPARy correlated with the development of microcirculatory in HCC. PPARy is a novel prognostic indicator for evaluating of HCC.