生理药物代谢动力学模型及其在二甲苯危险度评价中的应用

Physiologically Based Pharmacokinetic Models for Use in Risk Assessment of Xylene

作为一种估测组织放射量的成熟工具,生理药物代谢动力学(PBPK)模型可用于模拟从化学物质的外暴露到靶位点的内暴露这一过程,以支持人体健康危险度的定量预测。笔者将从建立模型的一般步骤、评估模型的标准和模型在危险度评价中的应用三个方面进行综述,并以二甲苯为例详细介绍PBPK模型在危险度评价中的应用。

As a mature tool for estimating tissue dosimetry, physiologically based pharmacokinetic （PBPK） models are being used to simulate the process from an external chemical exposure to an internal exposure at a target site, for supporting quantitative predictions of risks to human health. This paper reviewed these models from three aspects： the general steps of model construction, the criteria of model evaluation, the use of model in risk assessment and taking xylene as an example particularly described the third aspect.