载酯蛋白A—I与急性呼吸道感染的关系

The clinical significance of serum apolipoprotein A-I to the diagnosis of acute respiratory infection

目的探讨急性呼吸道感染患者血清载酯蛋白A—I（ApoA-I）变化及临床意义。方法2006年12月至2007年7月入住上海交通大学附属第一人民医院急诊ICU及急诊观察室急性呼吸道感染患者为试验组（44例），根据降钙素原（PCT）的质量浓度进行分组，分为PCT〈0．5ng/ml组，0．5ng／ml≤PCT〈2ng／ml组，PCT≥2ng／ml组。41例健康体检者为对照组。试验组和对照组均在入院24h内测定静脉血中ApoA—I、PCT、C反应蛋白（CRP）和白蛋白水平。统计学方法计量资料用均数±标准差（-↑x±s）表示，应用SPSS12．0软件进行统计学分析，计量资料的比较采用t检验及方差分析，相关性分析采用直线相关分析，P〈0．05为差异具有统计学意义。结果随着PCT质量浓度增加，ApoA—I和血清白蛋白值越低而CRP值越高（P〈0．05）。结论ApoA—I与呼吸道感染的严重程度呈正相关，在较严重的呼吸道感染ApoA-I具有一定的诊断价值，表明这类患者存在脂质代谢紊乱。

Objective To investigate the changes of serum apolipoprotein A-I and its clinical significance to acute respiratory infection. Method Totally 44 patients with acute respiratory infection were divided into three groups according to various concentration of serum apolipoprotein A-I. They were procalcitonin（PCF） 〈 0.5 ng/ml group,0.5 ng/ml≤PCF〈 2 ng/ml group and PCF≥2 ng/ml group. We measured apolipoprotein A-I,C-reactive protein, procalcitonin and albumin within 24 hours after admission. Results With the increase of serum PCT, the production of ApoA-I and albumin were down-regulated, while CRP up-regulated. Conclusions Apolipoprotein A-I has a sound relationship with the acute respiratory infection. It can be used as one of the diagnostic criteria in severe infection patients who have disorders of lipometabolism.